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Abacavir (trade names include A-Bec, Abamune, Synabac, Virol, Ziagen, Ziagenavir) is an antiviral medication for systemic use from nucleoside and nucleotide reverse transcriptase inhibitors pharmacological group. This medicine is used for the treatment and prevention of HIV/AIDS. It is often indicated in combination with other antiretroviral drugs to treat HIV infection. Abacavir Sulfate (Ziagen) tablets works by inhibiting viral replication.
Abacavir, Lamivudine (Kivexa)
Abacavir, Dolutegravir + Lamivudine (Triumeq)
Abacavir, Lamivudine + Zidovudine (Trizivir)
Adefovir Dipivoxil (Hepsera)
Clevudine (Levovir, Revovir)
Entecavir (Baraclude, Entimate)
Lamivudine, Zidovudine (Combivir)
Lopinavir, Ritonavir (Kaletra)
Telbivudine (Sebivo, Tyzeka)
Tenofovir Alafenamide (Vemlidy)
Tenofovir Disoproxil (Viread)
Pharmacological and medical categories:
Antivirals for systemic use
Nucleoside reverse transcriptase inhibitors (NRTIs)
J - Antiinfectives for systemic use
J05 - Antivirals for systemic use
J05A - Direct acting antivirals
J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF06 - Abacavir
Human immunodeficiency virus [HIV] disease - B20
Indications and usage:
Ziagen (Abacavir Sulfate), a nucleoside analogue human immunodeficiency virus (HIV-1) reverse transcriptase inhibitor, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
Dosage and administration:
Before initiating Ziagen, screen for the HLA-B*5701 allele.
Adults: 600 mg of Abacavir daily, administered as either 300 mg twice daily or 600 mg once daily.
Pediatric patients aged 3 months and older: administered either once or twice daily. Dose should be calculated on body weight (kg) and should not exceed 600 mg daily.
Patients with hepatic impairment: mild hepatic impairment - 200 mg twice daily.
Dosage forms and strengths:
Ziagen (Abacavir Sulfate) tablets 300 mg scored.
Ziagen (Abacavir Sulfate) oral solution: 20 mg per mL.
There is no known specific treatment for overdose with Ziagen. If overdose occurs, the patient should be monitored and standard supportive treatment applied as required. It is not known whether abacavir can be removed by peritoneal dialysis or hemodialysis.
Presence of HLA-B*5701 allele.
Prior hypersensitivity reaction to abacavir.
Moderate or severe hepatic impairment.
Warnings and precautions:
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues.
Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy.
Side effects, adverse reactions:
The most commonly reported Abacavir adverse reactions of at least moderate intensity (incidence greater than or equal to 10%) in adult HIV-1 clinical trials were nausea, headache, malaise and fatigue, nausea and vomiting, and dreams/sleep disorders.
The most commonly reported adverse reactions of at least moderate intensity (incidence greater than or equal to 5%) in pediatric HIV-1 clinical trials were fever and/or chills, nausea and vomiting, skin rashes, and ear/nose/throat infections.
To report suspected adverse reactions, contact GlaxoSmithKline pharmaceutical compamy or your local FDA.
Methadone: an increased methadone dose may be required in a small number of patients.
Riociguat: the riociguat dose may need to be reduced.
Use in specific populations:
Lactation: women infected with HIV should be instructed not to breastfeed due to potential for HIV transmission.
B3 - Australia
C - United States (Risk cannot be ruled out)
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
A-Bec - Emcure Pharmaceuticals
Abac - Ranbaxy
Abamune - Cipla
Synabac - Synmedic Laboratories
Virol - Ranbaxy
Zepril - Richmond Laboratorios
Ziagen - GlaxoSmithKline
Ziagenavir - GlaxoSmithKline
APIs used in medicine in combinations with abacavir:
Abacavir main article on Wikipedia: https://en.wikipedia.org/wiki/Abacavir
Abacavir compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Abacavir
Abacavir Sulfate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/121490831
Abacavir on DrugBank: https://www.drugbank.ca/drugs/DB01048
Abacavir Sulfate on DrugBank: https://www.drugbank.ca/salts/DBSALT000871
Abacavir FAQ on MedlinePlus (revised 04/15/2019): https://medlineplus.gov/druginfo/meds/a699012.html
Ziagen (Abacavir Sulfate) film-coated tablets drug label info on DailyMed (revised April 13, 2010): https://dailymed.nlm.nih.gov/dailymed/lookup...
Abacavir Sulfate by Mylan Pharmaceuticals Inc. film-coated tablets drug label info on DailyMed (revised January 8, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Abacavir for sale on Pharma Doctor: https://pharma-doctor.com/abacavir.html
Abacavir containing drugs on Drugs-About.com: https://drugs-about.com/ing/abacavir.html
Ziagen (Abacavir Sulfate) tablets and oral solution official prescribing information and medication guide from the U.S. FDA (revised 03/2012): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Ziagen (Abacavir Sulfate) tablets and oral solution prescribing information and medication guide from GlaxoSmithKline pharmaceutical company (revised 11/2020): https://www.gsksource.com/pharma/content/dam/...
Abacavir 300 mg film-coated tablets package information leaflet Medicines.org.uk (revised 06/2019): https://www.medicines.org.uk/emc/files/pil.10525.pdf
Abamune (Abacavir Sulfate, Ziagen generic) 300 mg film-coated tablets prescribing information from Cipla pharmaceutical company (revised 06/2019): https://www.ciplamed.com/content/abamune-tablets
Revised: March 2021
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